[Lys(Ac)14]-Histone H3 (9-19) – 1 mg

Overview

The [Lys(Ac)14]-Histone H3 (9-19) peptide is a crucial player in the regulation of gene expression and chromatin dynamics. This peptide, acetylated at the lysine residue in the 14th position, has been shown to participate in the active promoter state, where its acetylation level is influenced by cis regulatory elements, including CpG content at promoters. Its role is becoming increasingly important in cancer research, particularly concerning ovarian epithelial tumors, where decreased expression levels of this peptide correlate with malignancy progression. This makes it a potential prognostic marker in oncological studies.

Key Features

• Acetylation at lysine residue 14 enhances binding interactions.
• Involved in regulating active promoter states and gene expression.
• Potential prognostic marker for ovarian epithelial tumors.
• Useful for studies on chromatin dynamics and transcription regulation.
• Available in a convenient 1 mg size.

Specifications

FAQ

What is the significance of acetylation in histone peptides?

Acetylation of histones, such as in [Lys(Ac)14]-Histone H3, is a modification that plays a pivotal role in regulating gene expression by altering chromatin structure, thereby facilitating or inhibiting transcription.

How can I use this peptide in my research?

This peptide can be utilized in various assays, including those assessing gene expression and chromatin modifications. It’s particularly relevant for studies examining the epigenetic changes associated with tumor progression.

Is this product suitable for diagnostic purposes?

While [Lys(Ac)14]-Histone H3 (9-19) shows promise as a prognostic marker in cancer, its application as a diagnostic tool should be approached with caution and further validated in clinical settings.

To explore our range of peptides and find additional tools for your research, consider checking out our selection of peptides or related products like the PKG substrate. For more specific applications, the Autocamtide-2 peptide might be of interest.

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