Beta-Amyloid (3-16) – 1 mg

Overview

Beta-Amyloid (3-16) is a critical peptide fragment, comprising amino acids 3 to 16 of beta-Amyloid (Aß). This particular sequence features an N-terminal deletion that significantly alters the coordination environment of the Cu2+ binding site. Recognized for its role in neurodegenerative conditions, particularly Alzheimer’s disease, this peptide serves as a valuable tool for researchers studying neurological markers and the complexities of protein interactions.

The peptide is notable due to its oxidation targets, particularly the histidine residues that coordinate with metal ions. Additionally, when either Glutamine (Q) or Glutamic acid (E) is present at the N-terminus, pyroglutamyl (pGlu) peptides can spontaneously form. This conversion from Q or E to pGlu is a natural process, contributing to the peptide’s stability and efficacy in research settings.

Key Features

• Consists of amino acids 3 to 16 of beta-Amyloid.
• N-terminal deletion that impacts the Cu2+ binding dynamics.
• Relevant in studies of Alzheimer’s and related disorders.
• Offers insights into oxidative stress and metal ion interactions.
• Ideal for use in assays designed to investigate protein behavior and interactions.

Specifications

Product Name	Beta-Amyloid (3-16)
Quantity	1 mg
Category	Peptides

FAQ

What is the significance of the N-terminal deletion in Beta-Amyloid (3-16)?

The N-terminal deletion modifies the coordination environment for the Cu2+ binding site, which can influence the peptide’s interaction with metal ions and its role in oxidative processes related to neurodegenerative diseases.

How can Beta-Amyloid (3-16) be used in research?

This peptide is valuable for studying the mechanisms of Alzheimer’s disease, particularly in exploring oxidative stress effects and the role of metal ions in protein aggregation and toxicity.

Where can I find related products?

To complement your research, consider exploring other peptides in our catalog. For example, you might be interested in our PKG Substrate or Autocamtide-2. Each product is designed to provide quality support to your specific research needs.

Whether you’re developing assays or conducting biochemical studies, Beta-Amyloid (3-16) is a must-have in your research arsenal.

Related Products

• CREBtide [KRREILSRRPSYR], 5-FAM labeled

Browse more in Peptides.