Thioflavin T UltraPure Grade – 1 g

Overview

The Thioflavin T UltraPure Grade is a premium benzothiazole dye renowned for its specific application as a fluorescent amyloid stain. With its capability to detect senile plaques containing the betaA4 peptide associated with Alzheimer’s disease, ThT serves as a vital tool in neurological research. This dye binds rapidly and exclusively to the anti-parallel beta-sheet fibrils formed from synthetic beta-amyloid (1-42), allowing researchers to visualize amyloid deposition effectively. Unlike other amyloid stains, ThT does not bind with monomer or oligomeric intermediates, making it a reliable choice for studying fibrillar formations.

Key Features

• High purity for reliable results
• Specifically targets amyloid fibrils in Alzheimer’s disease
• Characteristics include a 120 nm red shift upon binding
• Excitation peak at 450 nm for enhanced fluorescence detection

Specifications

FAQ

How does Thioflavin T work in detecting amyloid fibrils?

Thioflavin T binds selectively to the beta-sheet structures of amyloid fibrils. When bound, the dye undergoes a fluorescence shift, making it easy to visualize these structures under appropriate light conditions.

Can I use Thioflavin T for other applications besides Alzheimer’s research?

While Thioflavin T is primarily used for research related to Alzheimer’s disease, its unique binding properties may also have applications in studying other diseases involving amyloid fibrils.

What are the ideal experimental conditions for using Thioflavin T?

For optimal results, use Thioflavin T at the recommended concentrations and under conditions that favor the formation of the fibrillar beta-sheet structures. Ensure to consult the product literature for specific guidance.

If you’re interested in broadening your research toolkit, consider exploring other products in our catalog, such as Indo-1 AM and Calcein blue AM. They offer unique properties that may complement your studies.

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