[Asn23]-beta-amyloid (1-42), Iowa Mutation – 0.5 mg

Name: [Asn23]-beta-amyloid (1-42), Iowa Mutation | AnaSpec
SKU: AS-63705
Price: 364.00 USD
Availability: InStock

$364.00

[Asn23]-beta-amyloid (1-42), Iowa Mutation, missense mutation in APP at position 694. Mutated Aß aggregates rapidly and forms toxic fibrils.

SKU: AS-63705 Category: Peptides Tags: Alzheimer's research, Beta-Amyloid, peptides

Description
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Overview

The [Asn23]-beta-amyloid (1-42), Iowa Mutation is a crucial peptide for research on Alzheimer’s Disease, particularly in understanding the mechanisms behind neurodegeneration. This specific mutation involves a change from Aspartic Acid (Asp) to Asparagine (Asn) at position 23 in the beta-amyloid precursor protein (APP). This alteration is linked to severe cerebral amyloid beta-protein angiopathy (CAA), which is characterized by the rapid aggregation of mutated Aß peptides into toxic fibrils that can lead to cellular damage and promote neurodegenerative processes.

Key Features

High-quality synthetic peptide, ensuring accurate research results.
Designed specifically for studies related to Alzheimer’s Disease.
Supports your investigations into neurodegenerative mechanisms.
Available in a convenient 0.5 mg quantity for your research needs.
Derived from the well-studied Iowa mutation, enhancing relevance in scientific applications.

Specifications

Product Name	[Asn23]-beta-amyloid (1-42), Iowa Mutation
Quantity	0.5 mg
Mutation	Asn at position 23
Associated Disease	Alzheimer’s Disease

FAQ

What is the significance of the Iowa mutation in Alzheimer’s research?

The Iowa mutation (Asp23 to Asn) is known to accelerate the aggregation process of beta-amyloid peptides, forming toxic fibrils that contribute to the pathology of Alzheimer’s Disease. Studying this mutation helps identify potential therapeutic targets.

How should I store the [Asn23]-beta-amyloid peptide?

For optimal stability, store the peptide at -20°C. Always consult the product data sheet for specific storage instructions and handling guidelines.

Can this peptide be used in fluorescence studies?

Yes, the [Asn23]-beta-amyloid peptide can be utilized in various experimental setups, including fluorescence studies. For enhanced results, consider pairing it with our fluorescent labeling dyes, which can be found in our extensive catalog of peptides.

Explore the depths of Alzheimer’s research with our premium [Asn23]-beta-amyloid (1-42), Iowa Mutation. This peptide not only aids in understanding the genetic factors of Alzheimer’s but also serves as a vital tool for studying neurodegenerative processes. Whether you’re investigating beta-amyloid aggregation or developing new experimental assays, this product is essential. Don’t miss out, add this peptide to your lab’s resources today!