ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R – 1 mg

Overview

The ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R (1 mg) is a specialized peptide designed for use in assays that assess the activity of ADAMTS-4, also known as Aggrecanase-1. This enzyme is crucial for degrading aggrecan, a key component of cartilage, making it significant in studies related to osteoarthritis and other joint disorders. With its optimized fluorescence resonance energy transfer (FRET) properties, this peptide provides a reliable method for monitoring enzyme activity in real-time.

Key Features

• Designed specifically for measuring ADAMTS-4 activity.
• Optimized for high sensitivity with a FRET signal at Ex/Em = 340/420 nm.
• Critical tool for research into osteoarthritis and cartilage degradation.
• Comes in a convenient 1 mg format for easy handling.
• Compatible with standard laboratory fluorescence equipment.

Specifications

FAQ

What is the role of ADAMTS-4?

ADAMTS-4 is a protease that cleaves aggrecan, which is vital for cartilage structure. Its activity is significant in studies related to joint health and diseases like osteoarthritis.

How is the WAAG-3R substrate used in assays?

This FRET substrate provides a measurable fluorescent signal that indicates the activity of ADAMTS-4. When the enzyme cleaves the substrate, the resulting change in fluorescence can be monitored.

Where can I find more reagents for my research?

You can explore additional reagents suitable for your assays, including PKG SubstrateAutocamtide-2and CREBtide among our range of Peptides.