Keratin K18-C – 5 mg

Overview

Keratin K18-C, available in a 5 mg vial, is a highly specialized peptide designed for researchers focusing on human keratin biology. This peptide corresponds to the amino acids 26-38 of human keratin K18 and includes an additional C-terminal cysteine. This modification enhances its stability and potential for various applications in scientific research.

The human keratin K18 protein is an integral component of the cytoskeleton in epithelial cells, playing crucial roles in cell structure and function. It has garnered attention for its association with the 14-3-3 protein family, which binds keratin 18 in a phosphorylation-dependent manner. The phosphorylated state of K18, particularly at Ser33, is vital for its interaction with 14-3-3 proteins, influencing critical cell processes such as cell cycle regulation and stress response.

Key Features

• Corresponds to the amino acids 26-38 of human keratin K18.
• Includes an additional C-terminal cysteine for enhanced stability.
• Identical sequence to mouse K18, with a minor difference at residue 28.
• Engages with 14-3-3 proteins, which are important for cellular signaling.
• Essential for studying keratin phosphorylation and its biological implications.

Specifications

FAQ

What are the applications of Keratin K18-C?

Keratin K18-C is widely used in cell biology and biochemistry studies to investigate the role of keratins in cell structure and function. Its specificity for 14-3-3 proteins makes it particularly useful in research involving cell cycle regulation and phosphorylation processes.

How should I store Keratin K18-C?

For optimal stability, store Keratin K18-C in a cool, dry place away from direct sunlight. Follow the manufacturer’s guidelines for storage conditions to ensure the peptide remains effective for your research.

Can I use Keratin K18-C in vivo?

This peptide is primarily intended for in vitro studies. Its effects in vivo have not been extensively characterized, so caution is advised if considering applications outside of controlled laboratory environments.

For further research into peptides, consider exploring our comprehensive range of peptides that could complement your study of keratin’s biological functions.

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