[Lys(Ac)382]-p53 (361-393), human, biotin-labeled, amide – 1 mg

Overview

Introducing [Lys(Ac)382]-p53 (361-393), a biotin-labeled amide peptide derived from the critical residues 361-393 of the human p53 tumor suppressor protein. This peptide not only plays a vital role in cellular regulation but also features acetylation at Lys382, enhancing its stability and functionality. With the N-terminus biotinylation linked by a six-carbon linker, it’s designed for effective detection and interaction in biochemical assays.

Key Features

• Biotin-labeled for easy detection and binding.
• Amidated form enhances stability and bioactivity.
• Acetylated at Lys382 to increase half-life in vivo.
• Derived from the pivotal p53 tumor suppressor, crucial for cell cycle regulation.
• Versatile application in research on apoptosis and tumor biology.

Specifications

FAQ

What is the significance of acetylation at Lys382?

Acetylation at Lys382 of p53 is crucial as it decreases MDM2-mediated ubiquitination, leading to an increased half-life of the p53 protein. This modification is important in the regulation of p53’s role in apoptosis and cell cycle arrest.

How can I use this peptide in my research?

You can utilize [Lys(Ac)382]-p53 in a variety of experiments focused on understanding the apoptotic pathways and tumor suppression mechanisms in human cells. This peptide is particularly useful in assays that require direct interaction with biotin-binding proteins.

Is this peptide suitable for in vivo studies?

Yes, the acetylation modification improves its stability, making it suitable for in vivo studies to assess p53’s biological functions.

For enhanced research capabilities, explore our PKG Substrate or consider other related peptides. With [Lys(Ac)382]-p53, you can ensure precise measurement and detection, fitting seamlessly into your study of protein interactions and cancer biology. Don’t miss out on the opportunity to add this essential tool to your research toolkit, shop now!

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