Autocamtide-2-Related Inhibitory Peptide (AIP); CaMKII Inhibitor, myristoylated – 1 mg

Overview

The Autocamtide-2-Related Inhibitory Peptide (AIP) is a myristoylated form that serves as a highly effective and precise substrate competitive inhibitor for Calmodulin-Dependent Protein Kinase II (CaMKII). This peptide is essential for researchers working in neurobiology and related fields, as it provides critical insights into kinase activity. With a well-characterized mechanism, AIP allows you to explore the role of CaMKII in various physiological functions, making it a valuable addition to your laboratory toolkit.

Key Features

• Myristoylated form enhances cellular membrane penetration.
• Specific inhibitor targeting CaMKII to help elucidate its role in signaling pathways.
• Derived from Autocamtide-2, ensuring potency through a well-defined mechanism.
• Facilitates studies related to neurological and physiological indicators.

Specifications

FAQ

What is the mechanism of action for AIP?

AIP functions as a substrate competitive inhibitor, specifically targeting CaMKII. By mimicking the natural substrate, it effectively blocks the kinase’s ability to phosphorylate its target proteins.

How is the myristoylation beneficial?

The myristoylation modification enhances the peptide’s affinity for cellular membranes, improving its bioavailability and allowing for more effective inhibition of CaMKII within live cells.

Can AIP be used in conjunction with other peptides?

Yes, AIP can be combined with various other peptides to study signal transduction pathways. For example, you might consider pairing it with the CREBtide for comprehensive research on cellular signaling.

When you’re ready to incorporate AIP into your research, you can easily purchase it online at AnaSpec. Our comprehensive catalog includes a wide variety of peptides and related products, including our PKG substrate, which may complement your work with AIP. Explore our selection of peptides to find what best suits your needs.

Related Products

• PKG Substrate [RKRSRAE], Glasstide
• Autocamtide-2 [KKALRRQETVDAL]
• CREBtide [KRREILSRRPSYR], 5-FAM labeled