Biotin-Exendin 4

Overview

Biotin-Exendin 4 offers a powerful approach to understanding insulin release in response to food intake. This synthetic peptide is a potent agonist of the glucagon-like peptide 1 (GLP-1) receptor, stimulating insulin secretion for effective glucose management. Biotin-Exendin 4 is especially notable for its biotin modification at the N-terminus, enhancing its versatility in research and diagnostic applications.

Key Features

• Agonist of the GLP-1 receptor, promoting insulin secretion
• Biotin modification for easy detection and labeling
• Longer half-life than GLP-1, increasing potency
• Derived from the Gila monster, Heloderma suspectum
• 53% sequence homology with GLP-1

Specifications

FAQ

What role does Exendin 4 play in insulin release?

Exendin 4 acts as an agonist for the GLP-1 receptor, which is crucial for stimulating insulin secretion after meals, contributing to better glucose control.

How does the biotin modification benefit research?

The biotin modification at the N-terminus allows for convenient labeling and detection in various assays, facilitating the study of GLP-1 related pathways.

What makes Biotin-Exendin 4 different from GLP-1?

Biotin-Exendin 4 has a longer half-life in plasma compared to GLP-1, which enhances its effectiveness as an insulinotropic agent, making it a valuable tool in metabolic research.

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