Protease-Activated Receptor-3, PAR-3 (1-6), human – 1 mg

Overview

Introducing Protease-Activated Receptor-3, PAR-3 (1-6), a synthetic peptide that plays a significant role in cellular signaling. This peptide fragment contains the first six amino acids of the protease-activated receptor 3 (PAR-3), which has been shown to induce ERK activation in human carcinoma cells that naturally express both PAR-1 and PAR-3. By understanding how PAR-3 interacts with these receptors, researchers can gain valuable insights into endothelial permeability and its related signaling pathways.

Key Features

• Induces ERK activation in human carcinoma cells.
• Specific to human PAR-3 and PAR-1 signaling pathways.
• Potential applications in cancer research and therapeutic strategies.
• Completely loses function with alanine substitutions at critical positions 3, 4, and 6.
• Supports studies on the role of receptor dimerization in endothelial permeability.

Specifications

FAQ

What is the primary function of PAR-3?

PAR-3 regulates PAR-1 signaling through receptor dimerization, which can impact endothelial permeability. Its activation influences various cellular processes, particularly in cancer cells.

How does this peptide affect ERK activation?

This peptide fragment is designed to promote ERK activation in cells that express PAR-1 and PAR-3, making it a useful tool for studying signaling pathways in cancer research.

Why is alanine substitution critical in studying this peptide?

Substituting alanine into specific positions of the peptide (3, 4, and 6) effectively abolishes its signaling ability, highlighting the importance of these amino acids for maintaining function.

If you’re interested in exploring more about our selection of peptides, check out our extensive catalog. For related studies, you might also consider our PKG Substrate or Autocamtide-2, which are excellent for various proteomic applications. Make informed decisions with our quality products at your fingertips.

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