[Pyr3]-beta-Amyloid (3-40)

Overview

[Pyr3]-beta-Amyloid (3-40) is a crucial peptide in Alzheimer’s disease research, representing a N-terminally truncated and pyroglutamate-modified form of beta-Amyloid. This specific peptide is significant because it contributes to the formation of senile plaques, which are characteristic of Alzheimer’s pathology. The modified forms, namely Aß(3-40) and Aß(11-40), have shown increased toxicity and a greater tendency to aggregate compared to their non-modified counterparts. Understanding the role of these peptides can enhance your research into Alzheimer’s disease and its underlying mechanisms.

Key Features

• N-terminally truncated structure enhances stability.
• Pyroglutamate modification leads to increased aggregation.
• Higher toxicity levels compared to non-modified beta-Amyloid.
• Essential for models of Alzheimer’s disease.
• Ideal for use in various assay kits.

Specifications

Property	Details
Synonyms	[Pyr3]-Aβ(3-40)
MW	3,000 Da
Purity	≥95%
Format	Lyophilized powder
Storage	−20°C

FAQ

What is [Pyr3]-beta-Amyloid (3-40) used for?

This peptide is primarily used in research related to Alzheimer’s disease. It helps scientists study the aggregation of beta-Amyloid and its role in plaque formation.

How should I store [Pyr3]-beta-Amyloid (3-40)?

For optimal stability and longevity, store the peptide at −20°C. Make sure it is kept in a dry environment to prevent degradation.

Can I use this peptide in my assay kits?

Yes, [Pyr3]-beta-Amyloid (3-40) is compatible with various assay kits, making it a valuable component for your Alzheimer’s research projects. You might also find our range of PKG Substrate and other related products suitable for your experiments.

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Browse more in Peptides.