[Met(O)35]-beta-Amyloid (1-42) – 0.5 mg

Overview

The [Met(O)35]-beta-Amyloid (1-42) peptide, available in a 0.5 mg vial, is a crucial component in Alzheimer’s disease research. It is a modified form of beta-amyloid 1-42, the primary protein found in brain senile plaques. This peptide plays a significant role in the neurotoxic processes associated with this debilitating condition. The redox state of methionine at position 35 (Met-35) is particularly important, as it influences the peptide’s ability to induce oxidative stress in neuronal cells.

Key Features

• Modified beta-amyloid peptide, facilitating research into Alzheimer’s disease
• Met-35 is in the sulfoxide form, affecting its neurotoxic potential
• Useful for studying mechanisms of cell death via Bax and Bcl-2 pathways
• Valuable for assays investigating neurodegeneration and free radical production
• Available in 0.5 mg for convenient use in laboratory applications

Specifications

FAQ

What is the significance of the Met(O)35 modification?

The Met(O)35 modification alters the peptide’s redox state, impacting its neurotoxic activity and providing insights into the mechanisms of Alzheimer’s disease.

How should I store the [Met(O)35]-beta-Amyloid (1-42) peptide?

This peptide should be stored at -20°C to maintain stability and prevent degradation.

Can I use this peptide for in vivo studies?

This peptide is primarily intended for in vitro studies. If you are considering in vivo applications, further validation is recommended.

Explore related products to enhance your research, including PKG Substrate and Autocamtide-2or check our extensive catalog of peptides for more options.

Related Products

• CREBtide [KRREILSRRPSYR], 5-FAM labeled