[Arg6]-beta-Amyloid (1-40), England Mutation – 0.5 mg

Overview

When researching Alzheimer’s Disease, it’s crucial to have reliable compounds that can simulate the disease’s pathology. The [Arg6]-beta-Amyloid (1-40), England Mutation is a key peptide for studying the disease’s mechanisms. This peptide features a mutation where the histidine at position 6 is replaced by arginine, significantly changing its properties. This mutation has been shown to accelerate the kinetics of oligomer formation, which are critical in the progression of Alzheimer’s.

Key Features

• Assists in the study of Alzheimer’s Disease pathology.
• Accelerates oligomer formation, essential for fibril seed generation.
• More toxic to cultured neuronal cells, enhancing research relevance.
• Available in a 0.5 mg quantity, ideal for various experimental setups.
• High purity and quality from AnaSpec’s trusted peptide catalog.

Specifications

FAQ

What is the significance of the England mutation in beta-amyloid?

The England mutation, which replaces histidine with arginine at position 6, is associated with increased toxicity and enhanced oligomerization, making it relevant for Alzheimer’s research.

How can this peptide be used in experiments?

This peptide can be utilized in cell culture studies to evaluate its effects on neuronal cells, particularly its role in oligomer and fibril formation.

Is there a recommended storage method for this peptide?

It is recommended to store the [Arg6]-beta-Amyloid (1-40), England Mutation at -20°C to maintain its stability and effectiveness for future experiments.

For your research needs, consider pairing this peptide with other specifics like our PKG Substrate for enhanced results. Explore our complete line of peptides to find additional resources that complement your studies.

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