Calpain Substrate Suc-LLVY-AMC, fluorogenic substrate – 5 mg

Overview

The Calpain Substrate Suc-LLVY-AMC is a fluorogenic substrate designed for research involving calpains, which are intracellular Ca2+ dependent cysteine proteases. These enzymes play a critical role in cellular signaling by responding to calcium levels and cleaving specific proteins, which alters their functions. Understanding how calpains interact with various proteins is vital for studying numerous physiological and pathological processes, including ischemic injury, muscular dystrophy, diabetes, cataracts, atherosclerosis, Alzheimer’s disease, and cancer. With this substrate, you can explore calpain activity in your assays more effectively.

Key Features

• Fluorogenic substrate for precise calpain detection.
• High sensitivity and specificity for intracellular proteases.
• Useful in studies related to calcium signaling and associated diseases.
• Facilitates understanding of calpain function in cellular processes.
• Comes in a convenient 5 mg size for easy handling in the lab.

Specifications

FAQ

What are calpains?

Calpains are a family of cysteine proteases that require calcium for their activity. They play critical roles in cellular processes by cleaving various proteins in response to calcium signals.

How do I use the Calpain Substrate Suc-LLVY-AMC?

This substrate can be used in various assays to monitor calpain activity. It produces a fluorogenic signal upon cleavage, allowing for easy detection and quantification of calpain activity in your samples.

What types of studies can benefit from this substrate?

Research involving calcium signaling, cellular responses to injury, and the pathology of diseases like Alzheimer’s and cancer are some areas that can greatly benefit from using the Calpain Substrate Suc-LLVY-AMC. Additionally, researchers studying protease inhibitors might find this substrate particularly useful for their experiments.

To further explore your options, you might want to check out our PKG Substrate or consider using Autocamtide-2 in conjunction with this product for enhanced insights into protease activities.

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• CREBtide [KRREILSRRPSYR], 5-FAM labeled

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