[Asn7]-beta-Amyloid (1-42), Tottori-Japanese Mutation – 0.5 mg

Overview

The [Asn7]-beta-Amyloid (1-42), Tottori-Japanese Mutation is a unique peptide that plays a significant role in Alzheimer’s disease research. This peptide is characterized by a specific mutation at the peptide N terminus, which is known to accelerate the formation of oligomers and promote the development of fibrils that exhibit heightened toxicity to neuronal cells. Understanding the implications of this mutation is crucial for researchers focused on the pathogenesis of Alzheimer’s disease, as it provides insights into how beta-amyloid peptides contribute to neurodegeneration.

Key Features

• 0.5 mg of highly purified [Asn7]-beta-Amyloid (1-42) peptide
• Tottori-Japanese mutation with D7N substitution
• Increased kinetics of oligomer formation
• Enhances fibril seed activity
• More toxic to neuronal cells compared to other variants

Specifications

FAQ

What is the significance of the Tottori-Japanese mutation?

This mutation in the beta amyloid precursor gene accelerates the oligomerization process and enhances the toxicity of the resulting peptides to neurons, making it a vital area of study for Alzheimer’s disease.

How does this peptide compare to other beta-amyloid variants?

The [Asn7]-beta-Amyloid (1-42) variant with the Tottori mutation is shown to be more toxic to neuronal cells and to accelerate the kinetics of oligomer formation more effectively than some other beta-amyloid variants.

What applications can I use this peptide for?

This peptide is primarily used in Alzheimer’s disease research, specifically for studying the mechanisms of neurotoxicity and oligomerization in beta-amyloid peptides. It can also be relevant in developing therapeutic interventions targeting Alzheimer’s disease.

If you’re ready to advance your research in neurodegenerative diseases, consider adding the [Asn7]-beta-Amyloid (1-42), Tottori-Japanese Mutation to your lab’s inventory. With its unique properties and significant impact on Alzheimer’s pathology, it’s an essential tool for any research focused on understanding and combating this complex disease.

Related Products

• PKG Substrate [RKRSRAE], Glasstide
• Autocamtide-2 [KKALRRQETVDAL]
• CREBtide [KRREILSRRPSYR], 5-FAM labeled

Browse more in Peptides.